杨磊博士，副主任技师

E-mail：ragemydream@email.tjut.edu.cn

教育及科研经历

2010.09-2013.07天津医科大学 医学博士导师：汤华

2007.09-2010.07南开大学 理学硕士 导师：曹勃阳

2003.9-2007.7天津科技大学 理学学士

研究方向:

1、非编码miRNA与宫颈癌发生发展过程中调控作用的研究

2、非编码miRNA介导微生物诱发肿瘤发生过程中作用的研究

基金项目：

1、国家自然科学基金，81602403，MPB83蛋白诱导NF-κBp65核转位抑制肿瘤细胞凋亡过程中miR-130b作用机制的研究，2017.01-2019.12，17万，主持

论文著作:

1、Wang Y#, Yang L#, Fan C#, Mu H*, Han M, Liu T, Xie L, Gao Q. miR-130b Expression Level Changes Promote Cervical Cancer Cell Proliferation But Inhibit its Apoptosis by Targeting CDKN1A Gene. Curr Cancer Drug Targets. 2022 Jan 11. Epub ahead of print.

2、Yang L, Yang B, Wang Y, Liu T, He Z, Zhao H, Xie L, Mu H*. The CTIP-mediated repair of TNF-alpha-induced DNA double-strand break was impaired by miR-130b in cervical cancer cell, Cell Biochemistry and Function, 2019, 10, 37(7) :534-544.

3、Yang L#, Wang Y#, Shi S#, Xie L, Liu T, Wang Y, Mu H*. The TNF-α-induced expression of miR-130b protects cervical cancer cells from the cytotoxicity of TNF-α. FEBS Open Bio 2018, 8(4):614-627.

4、Yang L, Wang YL, Dai JC, Liu M, Li X, Tang H*. Biochemical properties of Bacillus Calmette Guerin ribonuclease III. J Basic Microbiol, 2015, 56(4):392-404.

5、Yang L#, Wang YL#, Liu S#, Zhang PP, Chen Z, Liu M，Tang H*. miR-181b promotes cell proliferation and reduces apoptosis by repressing the expression of adenylyl cyclase 9 (AC9) in cervical cancer cells, FEBS Lett, 2014, 588(1):124-130.