张鹏博士，助理研究员
通讯地址：天津理工大学，生命健康智能检测研究院
E-mail：zpeng@email.tjut.edu.cn
教育及科研经历
2022.01-至今 天津理工大学，生命健康智能检测研究院
2017.09-2021.12 南开大学理学博士导师：罗义
2014.09-2017.07 海南大学农学硕士导师：骆焱平
2010.09-2014.07 海南大学工学学士
担任Food Science and Human Wellness和Journal of Future Foods两本期刊的青年编委，同时长期担任Journal of Controlled Release、ACS Nano、BMC Microbiology以及Food Science and Human Wellness, Journal of Future Foods等SCI期刊的审稿人。参与编写行业标准一项——《蚯蚓养殖技术规程》（标准号T/APEP 1034-2025）。作为主要完成人之一，获得2025年天津市科技进步奖三等奖（获奖项目：糖尿病合并感染精准诊疗关键技术及应用）。多次在全国环境化学大会和全国生态毒理学大会做学术报告。
主持或参加科研项目情况：
项目：国自然（面上）：人体肠道菌群中耐药基因分布和增殖机制研究（参与）；
国自然（青年）：根除幽门螺杆菌对人体肠道菌群中耐药基因分布和细菌耐药性进化机制，30万（主持）；
重点实验室开放基金课题：肠道菌群影响变形杆菌泌尿系统感染的机制研究，5万（主持）。
研究方向:
1、肠道微环境中ARGs增殖及肠道细菌耐药性进化机制研究；并基于组学和动物模型结合的手段研究异生质与肠道菌群的相互作用，及其可能的健康风险。
2、靶向治疗消化系统疾病的药物合成，及基于胆汁酸、生物多糖、脂质体和PLGA等材料构建高效的药物递送系统。
论文著作:
1. Zhang, P., Zhao, M., Cheng, Z., Ding, Y., Xia, S., & Guo, J. Bile acid metabolism dysregulation following Helicobacter pylori eradication promotes plasmid-mediated antimicrobial resistance in the gut microbiome. The ISME journal, wrag126. 2026, Advance online publication. https://doi.org/10.1093/ismejo/wrag126.
2. Zhao, M., Zhou, H., Jiang, R., Gao, Y., Zhang, P., & Wang, F. Colon-targeted alginate/chitosan microspheres for co-delivery of synbiotics and nanozymes ameliorate inflammatory bowel disease. Food research international. 2026, 239, 119533.
3. Liu, H., Han, B., Yao, H., Wang, J., Xv, F., Xv, Y., Zhang, M., Lin, M., Li, Z., Wang, S., Zhang, Y., Gao, J., Zhang, Y., & Zhang, P. Robot-assisted gait training alleviates the symptoms of acute ischemic stroke via regulating gut microbiota composition and function. Frontiers in cellular and infection microbiology. 2026, 16, 1810501.
4. Li, S., Zhang, P., Li, Y., Zhao, M., & Deng, H. Interface-Engineered Oral Hybrid Nanotherapeutics Combining Cerium Nanozymes and Extracellular Vesicles for Multimodal Regulation of Inflammatory Bowel Disease. ACS applied materials & interfaces. 2026, 18(6), 10416–10427.
5. Zhao, M., Zhang, Y., Liu, S., Wang, F., & Zhang, P. Eradication of Helicobacter pylori reshapes gut microbiota and facilitates the evolution of antimicrobial resistance through gene transfer and genomic mutations in the gut. BMC microbiology. 2025, 25(1), 90.
6. Zhang, P., Cheng, Z., Cao, Y., Liu, S., & Zhao, M. Genomic epidemiology of antimicrobial resistance in Proteus mirabilis: core genome and plasmid-mediated drivers. BMC microbiology. 2025, 26(1), 89.
7. Zhao, M., Tang, F., Huang, X., Ma, J., Wang, F., &Zhang, P. Polysaccharide Isolated from Agaricus blazei Murill Alleviates Intestinal Ischemia/Reperfusion Injury through Regulating Gut Microbiota and Mitigating Inflammation in Mice.Journal of agricultural and food chemistry. 2024, 72(4), 2202–2213.
8. Liu, L., Lu, X., Li, S., & Zhang, P. Polysaccharides isolated from Hibiscus sabdariffa L. mitigate intestinal radiation injury through relieving mucosal inflammation and reshaping gut microbiota in mice. Journal of Functional Foods. 2024, 121.
9. Zhao, M., Ma, J., Liu, H., Luo, Y., Deng, H., Wang, D., Wang, F., & Zhang, P. The Gut Microbiota Contributes to Systemic Responses and Liver Injury in Gut-Derived Sepsis. Microorganisms. 2023, 11(7), 1741.
10. Gao, Y., Zhang, P., Wei, Y., Ye, C., Mao, D., Xia, D., & Luo, Y. Porphyromonas gingivalis exacerbates alcoholic liver disease by altering gut microbiota composition and host immune response in mice. Journal of clinical periodontology. 2023, 50(9), 1253–1263.
11. Zhang P., Zheng L., Duan Y., Gao Y., Gao H., Mao D., Luo Y.. Gut microbiota exaggerates triclosan-induced liver injury via gut-liver axis. J Hazard Mater. 2022, 421:126707.
12. Zhang P., Mao D., Gao H., Zheng L., Chen Z., Gao Y., Duan Y., Guo J., Luo Y., Ren H. Colonization of gut microbiota by plasmid-carrying bacteria is facilitated by evolutionary adaptation to antibiotic treatment. ISME J. 2021 Dec 13.
13. Meng, D., Zhang, P., Li, S., Ho, C. T., Zhao, H. Antioxidant activity evaluation of dietary phytochemicals using Saccharomyces cerevisiae as a model. Journal of functional foods. 2017, 38: 36-44.
14. Meng, D., Zhang, P., Zhang, L., Wang, H., Ho, C. T., Li, S., Zhao, H. Detection of cellular redox reactions and antioxidant activity assays. Journal of Functional Foods. 2017, 37:467-479.
