张巍博士，副研究员
通讯地址：天津理工大学生命健康智能检测研究院
电话：022-60215055
邮箱：wei_zhang@email.tjut.edu.cn
教育和科研经历
2010/09-2014/06，吉林大学，学士
2014/08-2020/01，中国科学院长春应用化学研究所，博士
2020/01-至今，天津理工大学，生命健康智能检测研究院
科研方向：建立体外仿生三维细胞培养平台
具体方向：
1、开发动态图案化干细胞命运操控平台
2、3D仿生肿瘤微环境平台的构建及肿瘤发生发展机制探索
科研项目：
1、国家自然科学基金青年项目，可模拟肿瘤微环境的3D高分子水凝胶构建及应用研究，2023.01-2025.12，30万，主持。
2、卫健委项目，构筑贮藏型细菌纤维素透皮贴用于玫瑰痤疮的治疗研究，2025-12-01至2026-11-30，0.5万元，参与。
3、国家自然科学基金委员会，面上项目，51973214，多组分反应制备生物医用纳米材料，2020-01-01至2023-12-31，59万元，参与。
4、国家自然科学基金委员会，面上项目，51773197,肿瘤微环境响应的anti-PD-1/PD-L1抗体囊泡用于癌症化疗/免疫协同治疗，2018-01-01至2021-12-31，58万元，参与。
论文著作：
1、Pan, X., Zhu, S., Cu, W., Jin, L., Chen, J., Zhang, X.,Zhang, W.(通讯作者), Wang, T. A Versatile Multidrug Coloaded Nanoplatform Integrating Photothermal-Differentiation-Chemotherapy for Breast Cancer Stemness Inhibition. Biomacromolecules 2026, 27, 1247-1259.IF:5.4
2、Shi, B., Lou, X., Ma, F., Nie, Y., Chen, H., Huang, Y.,Zhang, W.(通讯作者), Wang, T. Perylene-mediated cytoskeletal dysfunction remodels cancer-associated fibroblasts to augment antitumor immunotherapy. Advanced Healthcare Materials 2024,13(11), 2303837.IF:9.6
3、Cui, W., Zhu, S., Pan, X.,Zhang, W.(通讯作者), Wang, T. Gold (III) porphyrin-metal-polyphenolic nanocomplexes: breaking intracellular redox environment for enhancing mild-temperature photothermal therapy. ACS Applied Materials & Interfaces 2024, 16(24): 30810-30818.IF:8.2
4、Lou X.; Wang H.; Liu Y.; Huang Y.; Liu Z.;Zhang, W.(通讯作者); Tie W.; Perylene-Based Reactive Oxygen Species Supergenerator for Immunogenic Photochemotherapy against Hypoxic Tumors,Angewandte Chemistry International Edition, 2023, 62, e202214586.IF:16.823
5、Zhang B., Zheng R., Liu Y., Lou X.,Zhang, W., Cui Z.,Huang Y.,Tie W., Perylene-Mediated Electron Leakage in Respiratory Chain to Trigger Endogenous ROS Burst for Hypoxic Cancer Chemo-Immunotherapy,Advanced Science, 2023, 10(3): 2204498. IF:17.521
6、Zhang, W., Lin, W.; Li, C.; Liu, S.; Hu, X.; Xie, Z., Rational Design of BODIPY-Diketopyrrolopyrrole Conjugated Polymers for Photothermal Tumor Ablation. ACS Applied Materials&Interfaces 2019, 11, 32720-32728.IF:10.383
7、Zhang, W.; Lin, W.; Wang, X.; Li, C.; Liu, S.; Xie, Z., Hybrid Nanomaterials of ConjugatedPolymers and Albumin for Precise Photothermal Therapy. ACS Applied Materials&Interfaces 2019, 11, 278-287. IF:10.383
8、Zhang, W.; Lin, W.; Zheng, X.; He, S.; Xie, Z., Comparing Effects of Redox Sensitivity of Organic Nanoparticles to Photodynamic Activity. Chemistry of Materials 2017, 29, 1856-1863. IF:10.508
9、Zhang, W.; Lin, W.; Pei, Q.; Hu, X.; Xie, Z.; Jing, X., Redox-Hypersensitive Organic Nanoparticles for Selective Treatment of Cancer Cells. Chemistry of Materials 2016, 28, 4440-4446. IF:10.508
10、Zhang, W.; Xie, Z.; Jing, X., Diselenide organic molecules self-assembled nanomedicines for selective treatment of cancer cells. Journal of Controlled Release 2017, 259, e135. IF:11.467
11、Zhang, W.; Xie, Z., Fabrication of palladium nanoparticles as effective catalysts by using supramolecular gels. Chinese Chemical Letters 2016, 27, 77-80. IF:8.455
12、Zong, S.; Wang, X.; Lin, W.; Liu, S.;Zhang, W.⁕, Simple D-A-D Structural Bisbithiophenyl Diketopyrrolopyrrole as Efficient Bioimaging and Photothermal Agents. Bioconjugate Chemistry 2018, 29, 2619-2627. IF:6.069
13、Zhang, T.,Zhang, W.⁕, Zheng, M., Xie, Z., Near-infrared BODIPY-paclitaxel conjugates assembling organic nanoparticles for chemotherapy and bioimaging. Journal of colloid and interface science 2018, 514, 584-591. IF:9.965
14、Li, C., Lin, W., Liu, S.,Zhang, W.⁕, Xie, Z., Self-destructive PEG-BODIPY nanomaterials for imaging and phototherapy. Journal of Materials Chemistry B 2019, 7, 4655-4660. IF:7.571
