杜以晨博士，助理研究员

通讯地址：天津理工大学，生命健康智能检测研究院

E-mail：duyichen@email.tjut.edu.cn

教育及科研经历

2018.07-2021.09 南开大学 博士后 导师：孔德明

2013.09-2018.06 南开大学 分析化学专业 博士 导师：孔德明

2009.09-2013.06 延边大学 应用化学专业 学士

研究方向:

核酸即时检测平台的开发及其在疾病诊断中的应用

主持或参加科研项目（课题）情况:

1.国家自然科学基金委员会，青年项目，22404123，一体化多重核酸即时检测装置的开发与应用研究，在研，主持。

代表性研究成果和学术奖励情况

期刊论文:

1.Zihan Wang,† Fuwan Yang,† Shuai Zeng,† Rui Sun, Qifei Hu,Yichen Du*, An integrated valved microfluidic platform for rapid and simultaneous nucleic acid detection,Lab Chip,2026, 26, 507.

2.Y.-C. Du, S.-Y. Wang, Y.-X. Wang, J.-Y. Ma, D.-X. Wang, A.-N. Tang, De-Ming Kong*, Terminal deoxynucleotidyl transferase combined CRISPR-Cas12a amplification strategy for ultrasensitive detection of uracil-DNA glycosylase with zero background,Biosens. Bioelectron.,2021, 171, 112734.

3.Y.-C. Du, S.-Y. Wang, X.-Y. Li, Y.-X. Wang, A.-N. Tang, De-Ming Kong*, Terminal deoxynucleotidyl transferase-activated nicking enzyme amplification reaction for specific and sensitive detection of DNA methyltransferase and polynucleotide kinase,Biosens. Bioelectron.,2019, 145, 111700.

4.Y.-C. Du, Y.-X. Cui, X.-Y. Li; G.-Y. Sun, Y.-P. Zhang, A.-N. Tang, K. Kim, D.-M. Kong*, Terminal deoxynucleotidyl transferase and T7 exonuclease-aided amplification strategy for ultrasensitive detection of Uracil-DNA glycosylase,Anal. Chem.,2018, 90(14): 8629~8634.

5.Y.-C. Du, Y.-J. Zhu, X.-Y. Li, D.-M. Kong*. Amplified detection of genome-containing biological targets using terminal deoxynucleotidyl transferase-assisted rolling circle amplification.Chem. Commun.,2018, 54, 682-685.

6.Y.-C. Du, L.-N. Zhu, D.-M. Kong*. Label-free thioflavin T/G-quadruplex-based real-time strand displacement amplification for biosensing applications.Biosens. Bioelectron.,2016, 86, 811-817.

7.Y.-C. Du, H.-X. Jiang, Y.-F. Huo, G.-M. Han, D.-M. Kong*. Optimization of strand displacement amplification-sensitized G-quadruplex DNAzyme-based sensing system and its application in activity detection of uracil-DNA glycosylase.Biosens. Bioelectron.,2016, 77, 971-977.

授权专利：

1.王铁;杜以晨;曾帅;郝爽;于帆，一种用于核酸即时检测的滑动微流控装置，ZL202320574727.5

2.王铁;王子涵;杜以晨;胡祺飞；一种基于球形核酸检测探针的编码试纸条和试剂盒及应用，ZL 2025 1 0076850.8。