张鹏博士，助理研究员

通讯地址：天津理工大学，生命健康智能检测研究院

E-mail：zpeng@mail.nankai.edu.cn

教育及科研经历

2017.09-2021.12 南开大学理学博士导师：罗义

2014.09-2017.07 海南大学农学硕士导师：骆焱平

2010.09-2014.07 海南大学工学学士

主持或参加科研项目情况：

国自然（面上）：人体肠道菌群中耐药基因分布和增殖机制研究（参与）；

国自然（青年）：根除幽门螺杆菌对人体肠道菌群中耐药基因分布和细菌耐药性进化机制（主持）。

研究方向:

1、抗生素胁迫下肠道菌群中ARGs增殖及肠道细菌耐药性进化机制研究；并基于组学和动物模型结合的手段研究异生质与肠道菌群的相互作用，及其可能的健康风险。

2、靶向治疗肠道疾病的药物合成，及基于生物多糖、脂质体和PLGA等材料构建高效的药物递送系统。

论文著作:

1. Zhao, M., Tang, F., Huang, X., Ma, J., Wang, F., &Zhang, P. Polysaccharide Isolated from Agaricus blazei Murill Alleviates Intestinal Ischemia/Reperfusion Injury through Regulating Gut Microbiota and Mitigating Inflammation in Mice.Journal of agricultural and food chemistry. 2024, 72(4), 2202–2213.

2. Zhao, M., Ma, J., Liu, H., Luo, Y., Deng, H., Wang, D., Wang, F., &Zhang, P. The Gut Microbiota Contributes to Systemic Responses and Liver Injury in Gut-Derived Sepsis.Microorganisms. 2023, 11(7), 1741.

3. Gao, Y.,Zhang, P., Wei, Y., Ye, C., Mao, D., Xia, D., & Luo, Y.Porphyromonas gingivalisexacerbates alcoholic liver disease by altering gut microbiota composition and host immune response in mice.Journal of clinical periodontology. 2023, 50(9), 1253–1263.

4. Zhang P., Zheng L., Duan Y., Gao Y., Gao H., Mao D., Luo Y.. Gut microbiota exaggerates triclosan-induced liver injury via gut-liver axis.J Hazard Mater.2022, 421:126707.

5. Zhang P., Mao D., Gao H., Zheng L., Chen Z., Gao Y., Duan Y., Guo J., Luo Y., Ren H. Colonization of gut microbiota by plasmid-carrying bacteria is facilitated by evolutionary adaptation to antibiotic treatment.ISME J. 2021 Dec 13.

6. Meng, D.,Zhang, P., Li, S., Ho, C. T., Zhao, H. Antioxidant activity evaluation of dietary phytochemicals using Saccharomyces cerevisiae as a model.Journal of functional foods. 2017, 38: 36-44.

7. Meng, D.,Zhang, P., Zhang, L., Wang, H., Ho, C. T., Li, S., Zhao, H. Detection of cellular redox reactions and antioxidant activity assays.Journal of Functional Foods. 2017, 37:467-479.