Lei Yang

Education and Research Experience:

2010.09-2013.07 Tianjin Medical University, Medical Doctor, Tutor: Hua Tang

2007.09-2010.07 Nankai University, Master of Science, Tutor: Bo-yang Cao

2003.09-2007.07 Tianjin University of Tianjin University of Science and Technology, Bachelor of Science

Research Interests:

1. The Researh on Regulation Role of Non-Coding miRNA in the Initiation and Development of Cervical Cancer

2. The Research on Mediation Role of Non-Coding miRNA in the Initiation of Microbia-Induced the Development of Tumor

Funds:

National Nature Science Fund, 81602403, The study on the Mechanism by which miR-130b Acts in the Inhibition of Tumor Cell Apoptosis Caused by the Enhancement of NF-κBp65

Nuclear Translocation which is Induced by MPB83 Protein, 2017.01-2019.12. Leading Researcher.

Literatures Published:

1. Wang Y#, Yang L#, Fan C#, Mu H*, Han M, Liu T, Xie L, Gao Q. miR-130b Expression Level Changes Promote Cervical Cancer Cell Proliferation But Inhibit its Apoptosis by Targeting CDKN1A Gene. Curr Cancer Drug Targets. 2022 Jan 11. Epub ahead of print. PMID: 35016595.

2. Yang L, Yang B, Wang Y, Liu T, He Z, Zhao H, Xie L, Mu H*. The CTIP-mediated repair of TNF-alpha-induced DNA double-strand break was impaired by miR-130b in cervical cancer cell, Cell Biochemistry and Function, 2019, 10, 37(7) :534-544.

3. Yang L#, Wang Y#, Shi S#, Xie L, Liu T, Wang Y, Mu H*. The TNF-α-induced expression of miR-130b protects cervical cancer cells from the cytotoxicity of TNF-α. FEBS Open Bio 2018, 8(4):614-627.

4. Yang L, Wang YL, Dai JC, Liu M, Li X, Tang H*. Biochemical properties of Bacillus Calmette Guerin ribonuclease III. J Basic Microbiol, 2015, 56(4):392-404.

5. Yang L#, Wang YL#, Liu S#, Zhang PP, Chen Z, Liu M，Tang H*. miR-181b promotes cell proliferation and reduces apoptosis by repressing the expression of adenylyl cyclase 9 (AC9) in cervical cancer cells, FEBS Lett, 2014, 588(1):124-130.